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Epidemiology
- Introduction Epidemiology
- History
- What % of preventable causes of death are due to tobacco compared to other causes?
- How does the prevalence of tobacco smoking vary across countries and gender
- In the USA what is the prevalence of smoking and other tobacco use?
- What social and ethnic factors alter smoking prevalence rates?
- List risk factors that increase smoking.
- What public health interventions can reduce smoking?
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Pharmacology
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Neurobiology
- Describe the Sequence of Factors that leads to Smoking Addiction
- What is the mechanism by which nicotine produces its biological and behavioral effects?
- How do nicotinic acetylcholine receptor subtypes regulate dopamine release?
- How could nicotine alter tonic and phasic DA release to increase cue salience?
- What is an important pathway that inhibits nicotine intake?
- Why would smokers try to keep Beta 2 nicotinic receptors in a desensitized state?
- What is the role of corticotrophin-releasing factor (CRF) in nicotine withdrawal?
- What is the role of the insula cortex in drug seeking.
- How do nicotine and alcohol interact?
- Could monoamine oxidase inhibition play a role in the effects of smoking?
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Genetics
- What is the heritability for nicotine dependence relative to other drugs of abuse?
- What is the Evidence for Genetic Factors in Smoking Initiation and Heavy Smoking?
- How Could Prevalence of Smoking Influence Estimates of Heritability?
- How do the Genetics of Nicotine Metabolism Relate to Smoking and Treatment ?
- How do variations in genes for acetylcholine receptors relate to smoking behaviors ?
- How does the Alpha 5 Receptor subunit Interact with Risk Factors for Smoking?
- How Does Stress Interact with Genetics of Monoamine Metabolism to Increase Smoking?
- How Would a Dopamine Receptor Allele Associated with Alcohol Addiction Effect Smoking ?
- How Could Prenatal Nicotine Exposure Alter Dopaninergic Function in Adulthood?
- Could Genotype Help Predict Response to Treatment?
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Effects of Regular Use and Difficulty Quitting
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