Individuals with low activity variants in cytochrome P4502A6 that metabolizes nicotine and cotinine have reduced metabolism of nicotine, smoke less and have higher nicotine levels while on nicotine patch treatment. Slower nicotine metabolizers have a higher quit rate on nicotine patch treatment.
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Genetics of Nicotine Metabolism
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Slower nicotine metabolism results in higher nicotine levels and a better quit rate on nicotine patch treatment.
Slower Nicotine Metabolism and Higher Quit Rate
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