- The risk allele of the dopamine D2 receptor (DRD2A1) is associated with reduced dopamine D2 receptor binding post mortem in the striatum of individuals without neurologic or psychiatric illness, and healthy individuals with the A1 allele have reduced D2 receptor availability measured with PET. Alcoholics have decreased availability of dopamine D2 Receptors, and the DRD2 A1 allele interacts with negative life event stress to increase the probability of alcoholism and it also increases alcohol use in adolescents with low parental rule setting.
- The DRD2 A1 allele is associated with smoking progression in adolescents.
The DRD2 A1 Allele and Smoking Progression
- The DRD2 A1 allele interacts with smoking cessation following acupuncture treatment.
DRD2 A1 Allele and Smoking Cessation