It is of major public-health importance to identify the long-term effects of adolescent alcohol exposure. There is considerable evidence that alcohol intake during adolescence produces neurobiologic alterations that persist into adult hood. A major factor limiting acute adult alcohol use is the development of motor impairment. It is of considerable importance that adolescent rats exposed to intermittent alcohol did during adolescence did not develop the normal age-related increase sensitivity of alcohol induced motor impairment. Thus the reduced alcohol induced motor impairment seen in adolescence persists in to adulthood. Similarly, alcohol exposure during adolescence also produces increased alcohol induced impairments and spatial memory that persists into adult hood. Thus the reduced motor impairment and increased cognitive impairment seen following acute alcohol in adolescent rats is also seen in adult hood in those rats exposed to alcohol during adolescence. This indicates that the exposure to alcohol during adolescence prevents the normal development of increased motor sensitivity and decreased cognitive sensitivity to acute alcohol that is seen in adults. Adolescent rats exposed to alcohol have increased risk taking in adult hood.
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