The most important known genetic factor is a deficiency in acetaldehyde dehydrogenase activity involved in the metabolism of acetaldehyde (acetaldehyde dehydrogenase-2). This results in higher levels of acetaldehyde that produce the adverse flushing reaction following alcohol ingestion. Although some individuals with this mutation can learn to continue to drink alcohol, individuals with this mutation have a much lower risk of developing alcohol dependence.
-
ALDH Deficiency Among Certain Populations is Associated with Lower Risk of Alcohol Dependence
(Constructed from data in: Eng MY, et al, Alcohol Research & Health, 30: 22-7, 2007; Konishi T, et al, Alcohol and Alcoholism, 38: 93-94, 2003; and Koob GF and Le Moal M, Neurobiology of Addiction, 181, 2006)
Skip to