When nicotine is administered immediately after alcohol, it increases the release of dopamine in the nucleus accumbens shell adult male rats had microdialysis performed following alcohol (time 0 min), nicotine (time 60 min), and a repeat alcohol dose immediately followed by nicotine dose (time 120 min). The effect of the alcohol-nicotine combination was blocked by the nicotine antagonistmechamylamine. (Constructed from data in Tizabi, Y. et al. Alcohol and Alcoholism, 42: 413, 2007) ©2007 NBEP