- Stress mechanisms play an integral role in addiction development and in vulnerability to relapse risk.
- Two basic types of stressors are
– Emotional– PhysiologicalReferences
1. Aguilar MA, Garcia-Pardo MP, Montagud-Romero S, Minarro J, Do Couto BR. Impact of Social Stress in Addiction to Psychostimulants: What we Know From Animal Models. Curr Pharm Des. Apr 5 2013.
1. Sim HR, Choi TY, Lee HJ, et al. Role of dopamine D2 receptors in plasticity of stress-induced addictive behaviours. Nature communications. 2013; 4, 1579.
1. Graziane NM, Polter AM, Briand LA, Pierce RC, Kauer JA. Kappa opioid receptors regulate stress-induced cocaine seeking and synaptic plasticity. Neuron 2013; 77(5), 942-954.
Stress can Activate Addiction Mechanisms