Stress as a Cause of Depression: Depression is twice as frequent in females than males, and it is well documented that depressed patients have an increase in the number of stressful life events prior to becoming depressed. However, it has been difficult to separate out whether depression leads to increased negative life events or negative life events lead to depression. When careful prospective studies are done and events are categorized, it has been found that a severe event can lead to depression within 6 months in up to 20% of women.
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